Health & Genetics

 Health & Genetics

Our Health is related to our Genetic architecture . Genes decide our fate. Each and every cell in Human body has the same DNA, but epigenetics decide our health. 

Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence.

Gene expression refers to how often or when proteins are created from the instructions within your genes. While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes “on” and “off.” Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment.

How Does Epigenetics Work?

Epigenetic changes affect gene expression in different ways. Types of epigenetic changes include:

DNA Methylation

DNA methylation works by adding a chemical group to DNA. Typically, this group is added to specific places on the DNA, where it blocks the proteins that attach to DNA to “read” the gene. This chemical group can be removed through a process called demethylation. Typically, methylation turns genes “off” and demethylation turns genes “on.”

Histone modification

DNA wraps around proteins called histones. DNA wrapped tightly around histones cannot be accessed by proteins that “read” the gene. Some genes are wrapped around histones and are turned “off” while some genes are not wrapped around histones and are turned “on.” Chemical groups can be added or removed from histones and change whether a gene is unwrapped or wrapped (“on” or “off”).

Non-coding RNA

Your DNA is used as instructions for making coding and non-coding RNA. Coding RNA is used to make proteins. Non-coding RNA helps control gene expression by attaching to coding RNA, along with certain proteins, to break down the coding RNA so that it cannot be used to make proteins. Non-coding RNA may also recruit proteins to modify histones to turn genes “on” or “off.”

Your epigenetics change as you age, both as part of normal development and aging and in response to your behaviors and environment.

Epigenetics and Development

Epigenetic changes begin before you are born. All your cells have the same genes but look and act differently. As you grow and develop, epigenetics helps determine which function a cell will have, for example, whether it will become a heart cell, nerve cell, or skin cell.

Example: Nerve cell vs. Muscle cell

Your muscle cells and nerve cells have the same DNA but work differently. A nerve cell transports information to other cells in your body. A muscle cell has a structure that aids in your body’s ability to move. Epigenetics allows the muscle cell to turn “on” genes to make proteins important for its job and turn “off” genes important for a nerve cell’s job.

Epigenetics and Age

Your epigenetics change throughout your life. Your epigenetics at birth is not the same as your epigenetics during childhood or adulthood.

Example: Study of newborn vs. 26-year-old vs. 103-year-old

DNA methylation at millions of sites were measured in a newborn, 26-year-old, and 103-year-old. The level of DNA methylation decreases with age. A newborn had the highest DNA methylation, the 103-year-old had the lowest DNA methylation, and the 26-year-old had a DNA methylation level between the newborn and 103-year-old .

Epigenetics and Reversibility

Not all epigenetic changes are permanent. Some epigenetic changes can be added or removed in response to changes in behavior or environment.

Example: Smokers vs. non-smokers vs. former smokers

Smoking can result in epigenetic changes. For example, at certain parts of the AHRR gene, smokers tend to have less DNA methylation than non-smokers. The difference is greater for heavy smokers and long-term smokers. After quitting smoking, former smokers can begin to have increased DNA methylation at this gene. Eventually, they can reach levels similar to those of non-smokers. In some cases, this can happen in under a year, but the length of time depends on how long and how much someone smoked before quitting .

Epigenetics and Health

Epigenetic changes can affect your health in different ways:

All the non communicable diseases like Diabetics, Coronary diseases, Kidney, liver, Bone conditions etc are all affected by your Epigenetics. Lifestyle changes can help you slow down progression of many non communicable disease conditions.

How to Know Genetic Risk level?

If you want to Check your Genetic risk level and prevent or reduce all non communicable disease, you need to test your Gene level epigenome. You can do it by online purchase of Genetic kit in which you can collect your Saliva (2ml only) and return to the testing company who will forward the results to you. It is amazing that you can do it so easily. Before purchasing the kit, please ensure that the company offers service in your country. Just visit the web site and learn more.

https://vieroots.com/eplimo-app/checkout-details/viegenome?waid=5833

SaiRaj.K.P.